Giant response of microbubble contrast agents oscillation in a high-intensity focused ultrasound field


  • Emil-Alexandru Brujan
  • Yoichiro Matsumoto


cavitation, microbubble contrast agents, giant oscillations


The interaction of microbubble contrast agents (BR14) with high-intensity focused ultrasound is investigated by high-speed photography. The experiments were conducted at an ultrasound frequency of 1.08 MHz with a peak negative pressure of 1.8 MPa. The microbubble oscillations run on a giant response with a long expansion phase followed by a violent collapse. The implications in high-intensity focused ultrasound surgery are also discussed.


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